Phillip Cocu's side reaped the benefits of the technically-gifted Dutchman over a period of 12 months as he provided a driving force in their midfield.
Van Ginkel scored seven goals and registered four assists in 15 league outings last season, which convinced De Boeren to prioritise his return to the Philips Stadion.
"I am very happy to be here. I will give my all to have a great season," the 24-year-old told PSV TV.
"I have been on loan at PSV twice and I am looking forward to making my third loan spell a big success."
Ginkel is joined in Cocu's squad by fellow new arrivals Hirving Lozano and Derrick Luckassen ahead of the new campaign.